Summary

This page shows a number of applications of IMP to biological systems. They can be adapted to tackle other similar problems, or to add new input data to an existing system.

Each system links to its web page, where all the input files can be found, complete with running instructions. Most systems are permanently archived (via DOIs) at Zenodo; newer systems are also deposited at PDB-Dev.

Every system is periodically tested with the latest version of IMP to make sure it works. The most recent version of IMP that it works with is shown below (or see all builds).

See the IMP manual for information on adding a new system to this page.

All systems with the PMI tag are shown. [Show all systems]

Show only systems with tag
affinity purification allostery analysis benchmark Brownian dynamics C3 C3b chemical crosslinks chromatin cysteine crosslinks drosophila melanogaster EM EM class average EM density map endogenous complex FoXS FRET glycosylation iC3 in-vivo FRET mass spectrometry model MODELLER multi-state MultiFit native mass spec PMI PMI1 quantitative crosslinking SAXS TADs threading X-ray yeast two-hybrid
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Integrative structures of the human Cop9 signalosome PubMed logo PDB-Dev

Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling [more...]

Last worked with IMP stable release (master branch): 2.13.0
Last worked with IMP nightly build (develop branch): 2020-08-14
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Model of Ecm29-proteasome complex PubMed logo PDB-Dev

Regulation of 26S proteasome via interaction with Ecm29 [more...]

Last worked with IMP stable release (master branch): 2.13.0
Last worked with IMP nightly build (develop branch): 2020-08-14
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Exocyst Complex PubMed logo PDB-Dev

Integrative Modeling of Yeast Exocyst Complex [more...]

Last worked with IMP nightly build (develop branch): 2020-08-14
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Integrative structures of the Nef-CD4-AP2 complex PubMed logo PDB-Dev

Integrative structure of the Nef-CD4(CD)-AP2(Δμ2-CTD) complex [more...]

Last worked with IMP nightly build (develop branch): 2020-08-14
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Pol II (G) complex PubMed logo PDB-Dev

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1 [more...]

Last worked with IMP stable release (master branch): 2.13.0
Last worked with IMP nightly build (develop branch): 2020-08-14
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PMI RNAPII Modeling Tutorial

Tutorial that demonstrates the modeling of RNA Polymerase II using Electron Microscopy density and chemical crosslinks [more...]

Last worked with IMP stable release (master branch): 2.13.0
Last worked with IMP nightly build (develop branch): 2020-08-14