This page shows a number of applications of IMP to biological systems. They can be adapted to tackle other similar problems, or to add new input data to an existing system.
Each system links to its web page, where all the input files can be found, complete with running instructions. Most systems are permanently archived (via DOIs) at Zenodo; newer systems are also deposited at PDB-Dev.
Every system is periodically tested with the latest version of IMP to make sure it works. The most recent version of IMP that it works with is shown below (or see all builds).
See the IMP manual for information on adding a new system to this page.
All systems with the MODELLER tag are shown. [Show all systems]
Determination of the molecular architecture of the 40S•eIF1•eIF3 translation initiation complex [more...]
Integrative structures of the human Cop9 signalosome PDB-Dev
Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling [more...]
Benchmark of the AllosMod method [more...]
Modeling of the bacterial molecular chaperone GroEL using 3D EM data and cnmultifit [more...]
Integrative structures of the Nef-CD4-AP2 complex PDB-Dev
Integrative structure of the Nef-CD4(CD)-AP2(Δμ2-CTD) complex [more...]
Modeling of the Nup133 subunit of the Nuclear Pore Complex [more...]
Modeling of the Nup82 subcomplex of the Nuclear Pore Complex [more...]
Modeling of the Nup84 subcomplex of the Nuclear Pore Complex [more...]
Modeling of the phosphodiesterase (PDE6) [more...]
Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex [more...]
Modeling of the SEA complex [more...]
The following systems are still under development and have not yet been tested against the public release of IMP:
Integrative structures of the A3G-CRL5-Vif-CBFb complex PDB-Dev
Integrative structure determination of the A3G-CRL5-Vif-CBFβ complex [more...]
Genetic interaction mapping informs integrative structure determination of protein complexes
Integrative Structure Determination using data from point mutant epistatic miniarray profile [more...]