IMP  2.0.1 The Integrative Modeling Platform
IMP.multifit_tools

MultiFit is a protocol for simultaneously fitting atomic structures of components into the cryo-electron microscopy (cryo-EM) density map of their assembly. It can also incorporate connectivity information from proteomics experiments (such as cross links), and can work with density maps at resolutions as low as 25A.

The component positions and orientations are optimized with respect to a scoring function that includes the quality-of-fit of components in the map, the protrusion of components from the map envelope, and the shape complementarity between pairs of components. The scoring function is optimized by an exact inference optimizer DOMINO that efficiently finds the global minimum in a discrete sampling space. The protocol employs the IMP::multifit module.

A webserver is also available.

Examples:

## Info

Maintainer: benmwebb