Re: [IMP-users] weights testing

[Ben Webb <>]

On 4/26/19 3:40 AM, Andrea Graziadei wrote:
> I am continuing to working with IMP/PMI for integrative modeling of a 
> protein complex using EM and crosslinking information. Ultimately, as in 
> the tutorial, I have 4 sets of restraints: excluded volume, 
> connectivity, crosslinks and gaussian.
>
> I would like to explore what weights to set.

Generally it shouldn't be necessary to modify the weights, except for 
possibly the EM restraint. There thus isn't really a protocol for 
optimizing the weights. Ideally each restraint would be Bayesian in 
nature such that weights are entirely unnecessary, although this isn't 
yet the case for EM.

	Ben
--
                      https://salilab.org/~ben/
"It is a capital mistake to theorize before one has data."
	- Sir Arthur Conan Doyle