IMP.foxs

FoXS

FoXS is a simple command line tool for determining small angle X-ray (SAXS) profiles.

The IMP.saxs module contains functions that, given an atomic protein structure, can calculate its SAXS profile using the Debye formula, and then fit this profile against the experimentally determined one. FoXS is a simple command line interface to this functionality which takes as input a number of PDB files and/or SAXS profiles. There is also a web server available.

Examples:

• Determination of a Nup133 structure

Info

Author(s): Dina Schneidman

Maintainer: duhovka

License: LGPL This library is free software; you can redistribute it and/or modify it under the terms of the GNU Lesser General Public License as published by the Free Software Foundation; either version 2 of the License, or (at your option) any later version.

Publications:

• Dina Schneidman-Duhovny, Michael Hammel, Andrej Sali, “FoXS: A Web server for Rapid Computation and Fitting of SAXS Profiles”, Nucleic Acids Research, 2010.
• Dina Schneidman-Duhovny, Michael Hammel, John A. Tainer, Andrej Sali, “Accurate SAXS profile computation and its assessment by contrast variation experiments”, Biophysical Journal , 2013.